منابع مشابه
Recent research on nickel carcinogenesis.
Research on nickel carcinogenesis from 1975 to March 1980 is reviewed. Epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of cancers of the nasal cavities and lungs. Clinical investigations have resulted in improved diagnosis, classification, and management of cancers of respiratory organs in nickel refinery workers. Carcinogenicity tes...
متن کاملMolecular mechanisms of nickel carcinogenesis.
Nickel treatment of intact cultured cells oxidized dichlorofluorescin to a fluorescent product indicating that nickel elevated the level of oxidants in cells. Nickel also caused an increase in crosslinking of amino acids to DNA and these complexes did not appear to involve the direct participation of Ni2+. Histidine, cysteine and tyrosine were prominent among the amino acids crosslinked to DNA....
متن کاملNickel carcinogenesis, mutation, epigenetics, or selection.
ofcells to carcinogenic nickel compounds induces many genes that are commonly expressed in cancer cells but not in normal cells. Nickel compounds have been well established as human carcinogens. Investigations into the molecular mechanisms of nickel car-cinogenesis have revealed that not all nickel compounds are equally carcinogenic: certain water-insoluble nickel compounds exhibit potent carci...
متن کاملThe role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis.
Increasing evidence demonstrates the reactive oxygen species (ROS) are implicated in metal carcinogenesis. Exposure of cultured Chinese hamster ovary (CHO) cells to several nickel compounds, i.e. NiS, Ni3S2, NiO (black and green), and NiCl2 has been shown to increase oxidation of 2',7-dichlorofluorescein to the fluorescent 2',7-dichlorofluorescein (DCF), suggesting that nickel compounds increas...
متن کاملPerspectives on the mechanism of nickel carcinogenesis gained from models of in vitro carcinogenesis.
This article briefly reviews the approach taken to understand the mechanism of nickel-induced neoplastic transformation. The initial phases of the studies were focused on particulate nickel compounds and on the regulation of phagocytosis of nickel compounds by cells undergoing transformation. The particulate nickel compounds most potent in inducing cell transformation were selectively phagocyti...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2003
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2003.08.021